Angiotensin Converting Enzyme Synonyms ACE; Angiotensin-I-Converting Enzyme

Laboratory Core Laboratory

Referral to Reference Laboratory

Request Form Routine Blood Requisition

Phone (212) 305-8600

Availability Daily, 24 hours

Turnaround Time 4 days

Specimen Blood

Volume 4 mL

Minimum Volume 1 mL serum

Container Gold top tube

Storage Instructions Separate serum.

Patient Preparation Patient must avoid having radioisotope scan administered 24 hours prior to venipuncture.

Causes for Rejection Recently administered radioisotopes, excessive hemolysis

Reference Range <15 years: 8-52 units/L;

15 years: 0-90 units/L

Use Angiotensin converting enzyme is increased in some cases of active sarcoidosis. Sensitivity approximately 75%, specificity approximately 95%. The sensitivity increases with the stage of the disease. Serial ACE determinations may be helpful in following the clinical course of sarcoidosis. ACE is not usually elevated in other lung diseases.

Methodology Enzymatic